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Pleural Effusion Caused by Prostaglandin E1 Preparation*

Hiroshi Watanabe, MD, PhD; Satoshi Anayama, MD; Tadahiro Horiuchi, MD; Eiichi Sato, MD, PhD; Yoshiki Hamada, MD, PhD; Hiroshi Ishihara, MD, PhD
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*From the Department of Orthopedic Surgery (Drs. Watanabe, Anayama, Horiuchi, Sato, and Hamada) and Second Department of Internal Medicine (Dr. Ishihara), Yamanashi Medical University, Yamanashi, Japan.

Correspondence to: Hiroshi Watanabe, MD, PhD, 1110 Shimokato, Tamaho-cho, Nakakomagun, Yamanashi, Japan 409-3821; e-mail: Hiroshiw123@hotmail.com



Chest. 2003;123(3):952-953. doi:10.1378/chest.123.3.952
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We encountered a case of bilateral pleural effusion associated with prostaglandin E1 (PGE1) preparation. A 75-year-old man underwent replacement surgery for an amputated hand. PGE1 was administered at 120 μg/d to maintain circulation after vascularization. From day 7 of administration, respiratory distress developed. On day 12, pleural effusion was observed bilaterally. By discontinuing PGE1 and improving hypoalbuminemia, pleural effusion resolved rapidly. This is the first case report of PGE1-induced pleural effusion; like other drug-induced pleural effusions, discontinuing the drug resulted in rapid improvement. Although a rare complication, pleural effusion has to be suspected when a patient receiving PGE1 experiences difficulty with breathing.

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