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Pembrey’s Dream : The Time Has Come for a Long-term Trial of Nocturnal Supplemental Nasal Oxygen to Treat Central Sleep Apnea in Congestive Heart Failure

Shahrokh Javaheri, MD, FCCP
Author and Funding Information

Affiliations: Cincinnati, OH
 ,  Dr. Javaheri is affiliated with the Sleep Disorders Laboratory, Department of Veterans Affairs Medical Center, Divisions of Pulmonary and Critical Care Medicine, and Cardiology, University of Cincinnati College of Medicine.

Correspondence to: Shahrokh Javaheri, MD, Professor of Medicine, Pulmonary Section (111F), VA Medical Center, 3200 Vine St, Cincinnati, OH 45220; e-mail: shahrokh.javaheri@med.va.gov



Chest. 2003;123(2):322-325. doi:10.1378/chest.123.2.322
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In 1907, Pembrey1 showed that supplemental nasal oxygen improved Cheyne-Stokes respiration in patients with congestive heart failure (CHF). Almost 100 years have passed, and there has been no long-term trial to determine whether treatment of central sleep apnea (CSA) with oxygen improves the natural history of CHF! Yet, CHF is highly prevalent and carries a poor prognosis,2 and CSA could be a potential contributory cause.3 Meanwhile, there are a number of studies showing that oxygen improves CSA and its pathophysiologic consequences.

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