Relapsing polychondritis is a rare systemic disease characterized by recurrent episodes of inflammation of cartilage. All types of cartilage may be involved, including cartilage of the ears and nose, peripheral joints, axial fibrocartilage, and in proteoglycan-rich sites such as the eyes, inner ears, blood vessels, and heart. The most common presenting symptom is ear pain due to auricular chondritis, which has been reported in 85–95% of cases. The respiratory manifestations of the disease are often severe and may be life-threatening. Half of the deaths with this disease are due to respiratory involvement. When relapsing polychondritis affects the entire tracheobronchial tree, the CT findings of the trachea may be similar to those seen in this case; features will include the following: diffuse thickening of the trachea and proximal bronchia, and thickened, calcified, cartilaginous rings. The tracheal walls have a nodular contour, and the lumen is narrowed and distorted. There may be tenderness over the thyroid and laryngeal cartilage as the larynx is frequently involved. Recurrent respiratory infections are common.