We describe a 37-year-old male engineer who presented with cough and dyspnea 3 weeks after exposure to dust resulting from the collapse of the World Trade Center (WTC). Radiographs of the chest and high-resolution CT demonstrated diffuse miliary nodularity. Lung biopsy specimens confirmed the presence of diffuse, noncaseating granulomatous nodules. Scanning electron microscopy and energy-dispersive radiograph analysis revealed large quantities of silicates. Cellular immunologic studies showed normal response to beryllium, and results of Kveim testing were negative. We suspect that exposure to one or more materials resulting from the WTC catastrophe may be implicated in the development of granulomatous pulmonary disease.