A 56-year-old white, male smoker with a history of type II diabetes mellitus presented to the hospital for elective resection of a subependymoma of the fourth ventricle of the brain. On the second postoperative day, a duodenal feeding tube was inadvertently placed into the right lung causing a pneumothorax, which was then treated with tube thoracostomy. On the fifth postoperative day, fever developed, along with tachypnea, purulent endotracheal aspirate, increasing fraction of inspired oxygen requirements, and left lower lung alveolar infiltrates on chest radiography. The patient was treated with levofloxacin, 750 mg/d, and his tracheal aspirate eventually grew Klebsiella oxytoca. He underwent a tracheostomy, was gradually weaned from the ventilator, and had his thoracostomy tube removed.