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Animal Models of Cigarette Smoke-Induced COPD*

Joanne L. Wright, MD; Andrew Churg, MD
Author and Funding Information

From the Department of Pathology, University of British Columbia, Vancouver, BC, Canada.

Correspondence to: J. L. Wright, MD, Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada; e-mail: jlwright@interchange.ubc.ca



Chest. 2002;122(6_suppl):301S-306S. doi:10.1378/chest.122.6_suppl.301S
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Objectives: To review the animal models of COPD, and to compare these data to those found in humans.

Results: Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a species to study. Remarkably little information is available about the biochemical and molecular changes induced by cigarette smoke in animal models.

Conclusions: Great insights into the pathology of chronic obstructive lung disease have been made using various animal models.


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