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Clinical Investigations: COUGH |

Measurement of Gastric Emptying in Gastroesophageal Reflux-Related Chronic Cough*

Jack A. Kastelik, MD; Warren Jackson, BSc; Trevor W. Davies, MSc; Graham A. Wright, MSc; Anthony E. Redington, MD; Kevin R. Wedgwood, MD; Alyn H. Morice, MD
Author and Funding Information

*From the Academic Department of Medicine (Drs. Kastelik, Redington, and Morice) and the Academic Department of Surgery (Mr. Jackson and Dr. Wedgwood), University of Hull, Castle Hill Hospital, Cottingham, UK; and the Department of Nuclear Medicine (Mr. Davies and Mr. Wright), Princess Royal Hospital, Hull, UK.

Correspondence to: Alyn H. Morice, MD, Academic Department of Medicine, University of Hull, Castle Hill Hospital, Castle Rd, Cottingham, East Yorkshire, HU16 5JQ, United Kingdom; e-mail: a.h.morice@hull.ac.uk



Chest. 2002;122(6):2038-2041. doi:10.1378/chest.122.6.2038
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Study objectives: Gastroesophageal reflux (GER) is one of the most common causes of chronic cough, but the mechanisms of GER-related cough are not well-understood. We tested the hypothesis that gastric emptying is delayed in patients with GER-related chronic cough.

Design: We studied 12 patients (7 women; mean age, 53 years; age range, 37 to 68 years) with GER-related chronic cough and a control group of 27 asymptomatic healthy volunteers (16 women; mean age, 37 years; age range, 18 to 62 years). Gastric emptying scintigraphy was performed, and the time at which 50% of the radiolabeled material had left the stomach (T1/2) was calculated.

Results: There was no statistically significant difference in T1/2 values between healthy volunteers and subjects with GER-related cough (99 ± 26 min vs 86 ± 20 min, respectively; difference between the means, 13 min [95% confidence interval, −4 to 30 min]; p = 0.13).

Conclusions: Gastric emptying was not delayed in patients with GER-related chronic cough. The measurement of gastric emptying did not therefore provide further insights into the mechanisms of GER-related cough or clinically relevant information that would assist in patient management.

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