0
Clinical Investigations: CARDIOLOGY |

Ventricular Arrhythmias in Patients With COPD Are Associated With QT Dispersion*

Pinar Yildiz, MD; Tufan Tükek, MD; Vakur Akkaya, MD; Ahmet Bilge Sözen, MD; Alaattin Yildiz, MD; Ferruh Korkut, MD; Veysel Yilmaz, MD
Author and Funding Information

*From the Department of Pulmonology (Drs. P. Yildiz and Yilmaz), Yedikule Chest Diseases and Chest Surgery Hospital; and the Departments of Cardiology (Drs. Tükek, Sözen, and Korkut) and Internal Medicine (Drs. Akkaya and A. Yildiz), Istanbul School of Medicine, Istanbul, Turkey.

Correspondence to: Pinar Yildiz, MD, Kartaltepe Mahallesi, Omür Sokak, No: 20/8, 34740, Bakirkoy, Istanbul, Turkey; e-mail: pinary70@hotmail.com



Chest. 2002;122(6):2055-2061. doi:10.1378/chest.122.6.2055
Text Size: A A A
Published online

Study objective: QT dispersion (QTd) and late potentials derived from signal-averaged ECG (SAECG) have been proposed as noninvasive predictors of cardiac arrhythmias that occur in patients with COPD. In this study, we aimed to investigate QTd and SAECG in patients with COPD.

Design: Cross-sectional study.

Setting: Teaching chest disease hospital and cardiology center in a university hospital.

Patients: Thirty patients with COPD (28 men and 2 women; mean ± SD age, 60 ± 9 years) and 31 age- and sex-matched control subjects (28 men and 3 women; mean age, 57 ± 7 years) were included.

Measurements and results: Respiratory function tests, arterial blood gas analyses, echocardiographic examinations, rhythm Holter recordings, and heart rate variability (HRV) analyses were performed in addition to the measurements of QT intervals and SAECG. Patients with COPD had higher rate of ventricular premature beats (VPBs) as compared to control subjects (924 ± 493 beats vs 35 ± 23 beats, p = 0.009). Eight patients with COPD (27%) had nonsustained runs of ventricular tachycardia (VT). QTd rates were significantly increased in patients with COPD as compared to control subjects (57.7 ± 9.9 ms vs 37.5 ± 8.2 ms, p < 0.001). On comparing patients with COPD with and without runs of VT, patients with VT had longer QTd (67 ± 10 ms vs 55 ± 8 ms, p = 0.001). However no difference in any HRV and late potential parameters were found between patients with COPD with and without runs of VT. VPB rates were strongly correlated with QTd in patients with COPD (r = 0.61, p < 0.001). On SAECG analysis, patients with COPD had significantly increased total QRS duration as compared to control subjects. Nine of the 30 patients with COPD (30%) had positive late potentials. However, QTd and VPB rates were also similar between patients with COPD with and without late potentials.

Conclusions: The development of ventricular arrhythmia in patients with COPD was associated with increased QTd. Increased QTd may be associated with autonomic changes seen in patients with COPD.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543