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Clinical Investigations: TECHNIQUES |

Clinical Significance of Myocardial Magnetic Resonance Abnormalities in Patients With Sarcoidosis*: A 1-Year Follow-up Study

Olivier Vignaux, MD; Robin Dhote, MD; Denis Duboc, MD, PhD; Philippe Blanche, MD; Daniel Dusser, MD; Simon Weber, MD; Paul Legmann, MD
Author and Funding Information

*From the Departments of Radiology (Drs. Vignaux and Legmann), Medicine (Drs. Dhote and Blanche), Pneumology (Dr. Duboc), and Cardiology (Drs. Dusser and Weber), Université René Descartes, Paris, France.

Correspondence to: Olivier Vignaux, MD, Université René Descartes, Hôpital Cochin, 27 rue du Fg Saint Jacques, 75679 Paris Cedex 14, France; e-mail: olivier.vignaux@cch.ap-hop-paris.fr



Chest. 2002;122(6):1895-1901. doi:10.1378/chest.122.6.1895
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Purpose: To assess the follow-up of patients with sarcoidosis and myocardial MRI abnormalities.

Materials and methods: Twelve patients with histologically proven sarcoidosis and highly suspected cardiac involvement underwent initial and 12-month follow-up cardiac assessment including cardiac MRI (T2-weighted, functional gradient echo, and T1-weighted gadolinium-diethylenetriamine penta-acetic acid-enhanced sequences). MRI abnormalities and clinical and MRI progression were scored by two observers.

Results: Six patients receiving corticosteroid therapy (including three patients with clinical cardiac involvement) were scored as having cleared or improved at MRI follow-up, while others were seen to have worsened or remained stable. The stability, improvement, or clearing of MRI findings were correlated with clinically stable, improved or cleared sarcoidosis, while a worsening at MRI follow-up was correlated with a worsening of sarcoidosis and, in one patient, was predictive of clinical cardiac involvement.

Conclusion: Cardiac MRI is a useful noninvasive method for the early diagnosis and follow-up of cardiac sarcoidosis.

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