Increasingly, evidence-based publications have put the practice of pulmonary medicine on firmer scientific footing. Physicians should, however, remain vigilant for the “pulmonary myth.” Daily practice of medicine generally continues to embrace practices often established by anecdotal information and common sense which are often found, after further investigation, to be flawed. Many of these practices have reached mythic proportions due to continued daily assertion on teaching rounds and their ongoing use in various practice environments. One such example is that the submission of a large volume of pleural fluid for cytologic evaluation, from patients with suspected pleural malignancy, has an improved yield over smaller volumes. This pulmonary practice appears to have been successfully unmasked as a myth in this edition of CHEST (see page 1913) by Sallach and colleagues.