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Laboratory and Animal Investigations |

Distribution of Calibrated Talc After Intrapleural Administration*: An Experimental Study in Rats

Anne Fraticelli, MD; Andrée Robaglia-Schlupp, MD; Helene Riera, BS; Suzanne Monjanel-Mouterde, MD; Pierre Cau, MD, PhD; Philippe Astoul, MD, PhD
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*From the Department of Pulmonary Diseases (Drs. Fraticelli and Astoul), Hôpital Sainte Marguerite, Marseille, France; Laboratoire de Biologie Cellulaire (Drs. Robaglia-Schlupp and Cau, and Ms. Riera), Hôpital de La Conception, Marseille, France; and Faculté de Pharmacie (Dr. Monjanel-Mouterde), Laboratoire de Pharmacodynamie, Marseille, France.

Correspondence to: Philippe Astoul, MD, PhD, Hôpital Sainte Marguerite, Department of Pulmonary Diseases, 270, Blvd Ste-Marguerite, 13274 Marseille Cedex 09, France; e-mail: pastoul@ap-hm.fr



Chest. 2002;122(5):1737-1741. doi:10.1378/chest.122.5.1737
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Study objective: Many reports have shown that talc is the most effective and least expensive agent for the creation of a pleural symphysis. However, its use still remains controversial due to severe acute respiratory side effects possibly related to the systemic dissemination of talc particles. The purpose of this study was to assess the distribution of calibrated talc after intrapleural administration in rats.

Material and methods: Thirty-seven Wistar male rats were randomly assigned to undergo pleurodesis by talc slurry (33 rats) or by simple chest tube drainage (control group; 4 rats). Forty milligrams of calibrated talc suspended in 1 mL sterile saline solution was injected into rats in the treated group. The animals were randomly assigned for autopsy at 24 or 72 h after pleural injection. Lungs, parietal pleura, diaphragm, liver, kidneys, spleen, pericardium, brain, and blood were assessed by polarized light for birefringent talc particle detection and counting.

Results: No deaths were observed. The autopsies showed no pleurodesis at 24 and 72 h. Despite high doses of talc (extrapolated from the dose of 10 g in a 70-kg adult man), few talc particles were found in the liver of two rats, in the spleen of one rat, and only one particle of talc was observed at the brain surface of the rat studied by scanning electron microscopy. No particles were found in the other organs, in particular in the contralateral lung and blood, contrasting with previously published results using noncalibrated talc particles.

Conclusions: The lack of systemic dispersion of talc particles, with the packaging talc we currently use in our clinical practice, is probably due to the size of the talc particles, which are larger than the other talc preparations. Calibrated talc is required in case of intrapleural administration for pleurodesis to avoid systemic dissemination and potential secondary acute respiratory failures.

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