These data suggested that a trial of therapeutic oxygen might improve daily function. The patient has been using supplemental oxygen for exercise, in the car, while sleeping, and/or “not feeling well” for the past 18 months. She uses variable flow between 2 L/min and 6 L/min with a mask and concentrator device at home, or a demand-delivery system with nasal prongs and portable tanks. Her functional capacity has gradually improved, and her prednisone dose has been substantially decreased for the first time in 8 years. She can now drive around town, walk in a shopping mall, and perform some household chores. In addition, the hair that had previously disappeared from her extremities (thought to be secondary to either the autoimmune disease or medication side effect) has regrown. Prior to oxygen therapy, her soft tissues in the extremities were painful with a boggy firmness, a fibromyalgia-like finding also thought to be part of the autoimmune syndrome. This symptom has gradually, but significantly, improved through a combination of body work (osteopathy and massage) and oxygen therapy. Prior to receiving supplemental oxygen, the same type of body work had been only minimally effective.