0
Clinical Investigations: TUBERCULOSIS |

Shifts of T4/T8 T Lymphocytes From BAL Fluid and Peripheral Blood by Clinical Grade in Patients With Pulmonary Tuberculosis*

Thomas C. Y. Tsao, MD, FCCP; Chi-Hong Chen, MD; Ji-hong Hong, MD, PhD; Meng-Jer Hsieh, MD; Kou-Ching Tsao, MSc; Cheng-Hei Lee, MD
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine (Drs. Tsao, Chen, Hong, Hsieh, and Lee), and Department of Clinical Pathology (Mr. Tsao), Chang Gung Memorial Hospital, Taipei, Taiwan.

Correspondence to: Thomas C. Y. Tsao, MD, FCCP, Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 199 Tun-Hwa North Rd, Taipei, Taiwan; e-mail: drtsao@cgmh.org.tw



Chest. 2002;122(4):1285-1291. doi:10.1378/chest.122.4.1285
Text Size: A A A
Published online

Objectives: We investigated the shifts of T4/T8 lymphocytes from BAL fluid (BALF) and peripheral blood by the clinical grade of pulmonary tuberculosis (TB), which is determined by factors such as extent of pulmonary involvement, fever, and loss of body weight.

Materials and methods: In order to explore these questions, BALF was collected from 45 patients presenting with active pulmonary TB and 14 healthy control subjects. The percentages for T-lymphocyte subpopulations, including CD4+, CD8+, and CD3+ T cells, were measured using two-color flow cytometry.

Results: A higher percentage of CD3+CD4+ T lymphocytes, with a relatively lower percentage of CD3+CD8+ T lymphocytes, was revealed for the patients with a higher grade of pulmonary TB, compared to patients with a lower grade of pulmonary TB, resulting in an increased BALF C4+/CD8+ ratio. By contrast, a higher percentage of CD3+CD8+ T lymphocytes with a relatively low percentage of CD3+CD4+ T lymphocytes was demonstrated for these patients with a higher grade of pulmonary TB, resulting in a decreased peripheral blood CD4+/CD8+ ratio.

Conclusions: Our findings suggest that compartmentalization of the CD4+ T lymphocytes in the infected lungs may occur for patients with higher grades of pulmonary TB.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543