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Special Report |

Pulmonary Embolism: What Have We Learned Since Virchow?*: Natural History, Pathophysiology, and Diagnosis

James E. Dalen, MD, MPH, Master FCCP
Author and Funding Information

*From the University of Arizona, Tucson, AZ.

Correspondence to: James E. Dalen, MD, MPH, Master FCCP, 1840 East River Rd, Suite 207, Tucson, AZ; e-mail: jamesdalen@yahoo.com



Chest. 2002;122(4):1440-1456. doi:10.1378/chest.122.4.1440
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Rudolf Virchow, the brilliant 19th century pathologist, was the first to recognize that blood clots in the pulmonary artery originate as venous thrombi. He stated: “The detachment of larger or smaller fragments from the end of the softening thrombus which are carried along by the current of blood and driven into remote vessels. This gives rise to the very frequent process on which I have bestowed the name of Embolia.”1

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