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Development of Neurologic Symptoms in a 26-Year-Old Woman Following Recovery From Methanol Intoxication*

Andrew P. Fontenot, MD; Victoria S. Pelak, MD
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*From the Departments of Medicine (Dr. Fontenot) and Neurology (Dr. Pelak), University of Colorado Health Sciences Center, Denver, CO.

Correspondence to: Andrew P. Fontenot, MD, Department of Medicine, University of Colorado Health Sciences Center (B164), 4200 East Ninth Ave, Denver, CO 80262; e-mail: andrew.fontenot@uchsc.edu



Chest. 2002;122(4):1436-1439. doi:10.1378/chest.122.4.1436
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Extract

A 26-year-old woman with no significant medical history presented with visual changes and altered mental status 36 h after the ingestion of methanol. On the evening of the ingestion, she reported blurred vision followed by the development of nausea and vomiting. On the following morning, family members noted a worsening mental status and persistent blurred vision, prompting presentation to the emergency department.

1Guggenheim, MA, Couch, JR, Weinberg, W (1971) Motor dysfunction as a permanent complication of methanol ingestion: presentation of a case with a beneficial response to levodopa treatment.Arch Neurol24,550-5542Kruse, JA Methanol poisoning.Intensive Care Med1992;18,391-3973Kuteifan, K, Oesterle, H, Tajahmady, T, et al Necrosis and haemorrhage of the putamen in methanol poisoning shown on MRI.Neuroradiology1998;40,158-1604Ley, CO, Gali, FG Parkinsonian syndrome after methanol intoxication.Eur Neurol1983;22,405-4095McLean, DR, Jacobs, H, Mielke, BW Methanol poisoning: a clinical and pathological study.Ann Neurol1980;8,161-1676Medina, L, Chi, TL, DeVivo, DC, et al MR findings in patients with subacute necrotizing encephalomyelopathy (Leigh syndrome): correlation with biochemical defect.AJNR Am J Neuroradiol1990;11,379-3847Moral, AR, Ayanoglu, HO, Erhan, E Putaminal necrosis after methanol intoxication.Intensive Care Med1997;23,234-2358Pelletier, J, Habib, MH, Khalil, R, et al Putaminal necrosis after methanol intoxication.J Neurol Neurosurg Psychiatry1992;55,234-2359Rubinstein, D, Escott, E, Kelly, JP Methanol intoxication with putaminal and white matter necrosis: MR and CT findings.AJNR Am J Neuroradiol1995;16,1492-149410Starosta-Rubinstein, S, Young, AB, Kluin, K, et al Clinical assessment of 31 patients with Wilson’s disease: correlations with structural changes on magnetic resonance imaging.Arch Neurol1987;44,365-370

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