Bookshelf |

Inhaled Steroids in Asthma: Optimizing Effects in the Airways FREE TO VIEW

Michelle Harkins, MD, FCCP
Author and Funding Information

University of New Mexico Health Sciences Center, Albuquerque, NM

Chest. 2002;122(2):757-758. doi:10.1378/chest.122.2.757-a
Text Size: A A A
Published online


By Robert P. Schleimer, Paul M. O’Byrne, Stanley J. Szefler, and Ralph Brattsand, eds. New York, NY: Marcel Dekker, 2002; 713 pp; $195

This book is the latest in the Lung Biology in Health and Disease series, outlining the effects of inhaled corticosteroids for asthma, from bench to bedside. As pulmonologists, we agree that inhaled corticosteroids are the mainstay of asthma therapy for persistent disease. Readers of this book will be led through concise chapters on the development of inhaled steroids; the molecular basis for steroid actions; determinants of lung selectivity; comparisons of various steroids, including side effects and animal and human research on lung inflammation; plus a section on future drug development. Each chapter is well written and brief. Current peer-reviewed studies pertinent to each section are discussed in order to make specific points. A nice feature at the end of each chapter is the question-and-answer section that emphasizes points made in the chapter and alludes to future research in the specific area.

There is an even balance between basic science and clinical study, including animal and human data. Selected sections of this book would appeal to the basic researcher, the pharmacologist, or the clinician. Each topic, however, is conveyed in an overview format so that one does not get too lost in molecular biology, pharmacokinetic formulas, or clinical disease monitoring. Appropriate graphs, tables, and figures complement the text and enhance its readability so that it would be useful to a varied audience. This book nicely outlines the basic mechanism for corticosteroid action, from glucocorticoid receptor gene regulation to blocking inflammatory chemokine expression. For clinicians, the overview of delivery devices and drug/patient determinants in bioavailability and side effects are helpful in providing a rationale for drug selection. Combination therapy for asthma is also covered. The final aspect of the book deals with future research into “soft steroids” and other molecular targets, such as nuclear transcription factors, in hopes of finding newer therapies with fewer side effects to make an impact on this disease. There is a slight bias to be more in-depth with budesonide over other corticosteroids, but that is reflective of the authors’ work with this drug. There is also some duplication of steroid side effects, with three chapters discussing variations on the theme.

Overall, Inhaled Steroids in Asthma: Optimizing Effects in the Airways is well written and covers a variety of aspects important in understanding the basic science and clinical implications of inhaled corticosteroids in asthma management.




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543