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Clinical Investigations: PLEURA |

Pleural Fluid Levels of Interleukin-5 and Eosinophils Are Closely Correlated*

K. H. Mohamed, MBBCh, MSc; Amany I. Abdelhamid, MBBCh, MSc; Y. C. Gary Lee, MBChB; Kirk B. Lane, PhD; Barrett Conner, MD; Michael Hawthorne, MD; Richard W. Light, MD, FCCP
Author and Funding Information

*From the Departments of Chest Diseases (Dr. Mohamed) and Clinical Pathology (Dr. Abdelhamid), Zagazig University Hospital, Zagazig, Egypt; and the Pulmonary Medicine Department (Drs. Lee, Lane, Conner, Hawthorne, and Light), Saint Thomas Hospital and Vanderbilt University, Nashville, TN.

Correspondence to: Richard W. Light, MD, FCCP, Director, Pulmonary Disease Program, Saint Thomas Hospital, PO Box 380, 4220 Harding Rd, Nashville, TN 37205; e-mail: rlight98@yahoo.com



Chest. 2002;122(2):576-580. doi:10.1378/chest.122.2.576
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Background: The mechanisms responsible for the accumulation of eosinophils in pleural fluid are not fully understood. The purpose of this study was to evaluate the relationship between eosinophil accumulation and the levels of interleukin (IL)-5, IL-3, and granulocyte/macrophage colony-simulating factor (GM-CSF) in pleural effusions.

Methods: We evaluated 30 patients with eosinophilic pleural effusions (eosinophil count > 10% nucleated cells in pleural fluid) and 10 patients with noneosinophilic pleural effusions. The patients with eosinophilic pleural effusions included 22 patients with post-coronary artery bypass graft surgery pleural effusions and 8 patients with eosinophilic pleural effusions caused by other causes. IL-5, IL-3, and GM-CSF in all pleural fluids were measured using enzyme-linked immunosorbent assay kits.

Results: The mean level of IL-5 in eosinophilic pleural effusions (283.1 ± 341.6 pg/mL) was significantly (p < 0.025) higher than that in the noneosinophilic effusions (28.2 ± 19.0 pg/mL). The absolute eosinophil count and percentage correlated significantly with the level of IL-5 in all patients (r = 0.55, p < 0.001, and r = 0.54, p < 0.001, respectively). There was no significant correlation between IL-5 levels and RBC counts in all patients (r = 0.24, p > 0.05). GM-CSF and IL-3 levels were below the detectable range in all pleural fluids.

Conclusion: There is a significant relationship between the levels of IL-5 in pleural fluid and the total number and percentage of eosinophils in the pleural fluid. IL-5 seems to be related to the eosinophil accumulation associated with blood or air in the pleural space and other eosinophilic pleural effusions.

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