During the last 6 months, transient lactatemia and/or lactic acidosis were observed in five patients admitted in our department for an asthma attack (Table 1
). All of these patients were initially treated with 5 mg of inhaled salbutamol before blood gas (and lactic acid) analysis was performed. No IV bronchodilators were administered, and methylprednisolone, 40 mg/d, was administered only after the first blood analysis. No clinical or laboratory indications of any alternative cause of lactatemia (eg, hypoxemia, hypoperfusion, sepsis) were identified, in accordance with previous reports.4 Serum lactate levels were not related with the severity of the airway obstruction or the degree of dyspnea. However, in all five cases, resolution of asthma symptoms was accomplished by intensive treatment with inhaled salbutamol. After 24 h, serum lactate levels had returned to normal without any specific treatment.