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Editorials |

Lung Cancer Screening: Conundrum or Contumacy?

Frederic W. Grannis, Jr, MD, FCCP
Author and Funding Information

Affiliations: Duarte, CA
 ,  Dr. Grannis is Head, Section of Thoracic Surgery, Department of General Oncologic Surgery, City of Hope National Medical Center.

Correspondence to: Frederic W. Grannis, Jr., MD, FCCP, Head, Section of Thoracic Surgery, Department of General Oncologic Surgery, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010; e-mail: fgrannis@coh.org



Chest. 2002;122(1):1-2. doi:10.1378/chest.122.1.1
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In this issue of CHEST (see page 329), Jerome Reich, MD, from the Kaiser Foundation Hospitals Center for Health Research, adds his voice to the chorus of epidemiologists who oppose screening for lung cancer (LC) with CT scanning outside of a prospective randomized controlled trial (RCT). He marshals evidence, proposes models to elucidate the medical and economic perils of LC screening, and exhorts clinicians to rally round the “gold standard” of the RCT. The author provides a very complete review of previous screening trials for LC. He discusses the hypothetical reasons for failure of these trials to demonstrate a reduction in population mortality and concludes that overdiagnosis bias (ODB) has been convincingly demonstrated.

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