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Fungal Endocarditis, 1995–2000

Lígia C. Pierrotti, MD; Larry M. Baddour, MD
Author and Funding Information

*From the Hospital das Clinicas (Dr. Pierrotti), University de São Paulo, São Paulo, Brazil; and the University of Tennessee Medical Center at Knoxville (Dr. Baddour), Knoxville, TN.

Correspondence to: Larry M. Baddour, MD, University of Tennessee, Medical Center at Knoxville, 1924 Alcoa Highway U-114; Knoxville, TN 37920-6999; lbaddour@mc.utmck.edu



Chest. 2002;122(1):302-310. doi:10.1378/chest.122.1.302
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One hundred fifty-two cases of fungal endocarditis (FE) were identified in the English-language literature between January 1, 1995, and June 30, 2000. Although the median age of patients (44 years) was relatively young, injection drug use was identified as a risk factor in only 4.1% of cases. Other factors, including underlying cardiac abnormalities (47.3%), prosthetic valves (44.6%), and central venous catheters (30.4%), were more commonly identified as predisposing conditions and reflect the changing epidemiology of the syndrome. Unfortunately, mortality remains unacceptably high, particularly for patients with Aspergillus-related FE. Novel therapies are needed to improve patient outcomes.


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