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The Clinical Spectrum of Pulmonary Aspergillosis*

Ayman O. Soubani, MD; Pranatharthi H. Chandrasekar, MD
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*From the Divisions of Pulmonary, Critical Care, and Sleep Medicine (Dr. Soubani) and Infectious Diseases (Dr. Chandrasekar), Wayne State University School of Medicine, Detroit, MI.

Correspondence to: Ayman O. Soubani, MD, Harper University Hospital, Division of Pulmonary, Critical Care, and Sleep Medicine, 3990 John R-3 Hudson, Detroit, MI 48201; e-mail: asoubani@intmed.wayne.edu



Chest. 2002;121(6):1988-1999. doi:10.1378/chest.121.6.1988
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Aspergillus is a ubiquitous fungus that causes a variety of clinical syndromes in the lung, ranging from aspergilloma in patients with lung cavities, to chronic necrotizing aspergillosis in those who are mildly immunocompromised or have chronic lung disease. Invasive pulmonary aspergillosis (IPA) is a severe and commonly fatal disease that is seen in immunocompromised patients, while allergic bronchopulmonary aspergillosis is a hypersensitivity reaction to Aspergillus antigens that mainly affects patients with asthma. In light of the increasing risk factors leading to IPA, such as organ transplantation and immunosuppressive therapy, and recent advances in the diagnosis and treatment of Aspergillus-related lung diseases, it is essential for clinicians to be familiar with the clinical presentation, diagnostic methods, and approach to management of the spectrum of pulmonary aspergillosis.

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