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P2Y2 Receptor Agonists*: A New Class of Medication Targeted at Improved Mucociliary Clearance

Donald J. Kellerman, PharmD
Author and Funding Information

*From Inspire Pharmaceuticals, Durham, NC.

Correspondence to: Donald J. Kellerman, PharmD, Sr. Vice President, Development, Inspire Pharmaceuticals, 4222 Emperor Blvd, Suite 470, Durham, NC 27703; e-mail: dk@inspirepharm.com



Chest. 2002;121(5_suppl):201S-205S. doi:10.1378/chest.121.5_suppl.201S
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Chronic bronchitis is in part characterized by mucus hypersecretion and the inability to clear airways of mucus. Despite years of research in this area, to date there are no pharmacologic therapies available to enhance or promote mucociliary clearance. P2Y2 receptor agonists are a new class of mucoactive compounds that are currently under development for this purpose. This article will review the pharmacology of P2Y2 receptor agonists, review the clinical studies performed to date, and highlight the challenges inherent in the development of therapies with these pharmacologic properties.

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