0
Articles |

Neutrophils and the Pathogenesis of COPD*

Robert A. Stockley, MD, DSc
Author and Funding Information

*From the Lung Resource Center, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

Correspondence to: R. A. Stockley, MD, DSc, Lung Resource Center, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK; e-mail: r.a.stockley@bham.ac.uk



Chest. 2002;121(5_suppl):151S-155S. doi:10.1378/chest.121.5_suppl.151S
Text Size: A A A
Published online

Extract

The polymorphonuclear leukocyte is a key effector cell of the secondary host defense system. This cell, however, also has been implicated in the pathogenesis of chronic lung disease for > 30 years. The association dates to an observation in 1963 that severe early-onset emphysema was associated with deficiency in α1-antitrypsin (α1-AT).1 The recognition that α1-AT was a serum protein that functioned as an endogenous inhibitor of serine proteinases suggested that an enzyme or enzymes, the activity of which normally was regulated by α1-AT, was responsible for the lung damage leading to emphysema. This chance observation led to the proteinase/antiproteinase theory of the pathogenesis of emphysema that is now accepted widely as a key mechanism of disease development.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543