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Death Associated With Rifampin and Pyrazinamide 2-Month Treatment of Latent Mycobacterium Tuberculosis*

Ann Medinger, MD, FCCP
Author and Funding Information

*From the Department of Veterans Affairs Medical Center, Washington, DC.

Correspondence to: Ann Medinger, MD, FCCP, 5605 Park St, Chevy Chase, MD 20815-3404; e-mail: medingerbeeny@erols.com



Chest. 2002;121(5):1710-1712. doi:10.1378/chest.121.5.1710
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We present the case of an elderly patient who died of fulminant hepatic failure in the course of receiving 2 months of treatment with pyrazinamide and rifampin for his latent tuberculosis. This 2-month course of treatment for latent tuberculosis is one of four options recently recommended by the Centers for Disease Control and Prevention. We discuss the safety of using this two-drug regimen to treat latent tuberculosis in stable elderly patients.


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