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Laboratory and Animal Investigations |

Perioperative Hemodynamic and Geometric Changes of the Left Ventricle During Cardiomyoplasty in Goats With Dilated Left Ventricle*

Gil Bolotin, MD, PhD; Roberto Lorusso, MD, PhD; Jan J. Schreuder, MD, PhD; Nahum Nesher, MD; Hans Kaulbach, MD; Gideon Uretzky, MD; Frederick van der Veen, PhD
Author and Funding Information

*From the Department of Cardiothoracic Surgery (Drs. Bolotin, Nesher, and Uretzky), Tel Aviv Sourasky Medical Center, Division of Cardiac Surgery, Tel Aviv, Israel; and the Cardiovascular Research Institute (Drs. Lorusso, Schreuder, Kaulbach, and van der Veen), Maastricht University Hospital, Maastricht, the Netherlands.

Correspondence to: Gil Bolotin, MD, PhD, the Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel; e-mail: bolotin@netvision.net.il



Chest. 2002;121(5):1628-1633. doi:10.1378/chest.121.5.1628
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Objective: Clinical data have suggested the occurrence of temporary short-term deterioration of the heart following cardiomyoplasty. The purpose of this study was to monitor the short-term hemodynamic effects of cardiomyoplasty in a goat model of a dilated left ventricle, using conductance catheters (ie, pressure-volume loops) and cardiac output measurements.

Methods: Eight female goats underwent acute cardiomyoplasty 8 to 12 weeks after left ventricular (LV) dilatation was induced by a carotid jugular arteriovenous shunt. The cardiomyoplasty procedure was monitored using a Swan-Ganz catheter for cardiac output measurements and a 12-electrode (dual-field) conductance catheter to LV pressure-volume loops.

Results: After wrapping the heart with the latissimus dorsi muscle, there was a significant reduction in both cardiac output and LV end-diastolic volume (LVEDV) at 10 min. Partial recovery was observed 45 min later.

Conclusion: A decrease in both cardiac output and LVEDV was observed following myocardial wrapping. This may explain some of the perioperative and postoperative morbidity and mortality observed following cardiomyoplasty.

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