The treatment for metastatic ameloblastoma has been somewhat elusive. In 1987, Lanham5 reviewed chemotherapeutic options and noted that doxorubicin, 5-fluorouracil, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, methotrexate, methotrexate with cyclophosphamide, cyclophosphamide, nitrogen mustard, vincristine, prednisone, bleomycin, 5- fluorouracil with dacarbazine, and 5-fluorouracil with doxorubicin did not produce any effective objective improvement. Whereas various studies10–11 have shown that ameloblastoma has responded unpredictably to radiation, Elliason et al11 point out that early radiotherapy failures occurred before development of megavoltage external irradiation. Significant resection with preservation of as much viable lung tissue as possible has been the treatment of choice, as this is the only way to offer a significant disease-free survival. In their 1993 case report, Sheppard et al9 reported a patient who underwent eight thoracotomies before achieving disease-free status with no limitation of activities.