The typical veteran was a white male, aged 57 years. There were no significant (p < 0.05) differences between groups as a function of demographic factors, treatment motivation variables, or health habits. About 26% of patients reported quitting all nicotine use at follow-up, and 80% of those still using tobacco claimed nicotine reduction. Neither the group that quit (χ2 test, 0.27; p = 0.60) nor the group that reduced tobacco use (χ2 test, 1.35; p = 0.25) showed significant differences; however, side effect profiles tended to be different. In response to a yes-no question concerning the presence of side effects, a higher percentage of patients in the 300-mg group complained of side effects than did patient in the 150-mg group (χ2 test, 3.47; p = 0.06), with the total number of side effects averaging 2.6 per patient in the 300-mg group vs 1.2 per patient in the 150-mg group (t test, 1.92; p = 0.06). Weight change did not vary significantly between groups.