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A Search for Linkage to Atopic Asthma in Candidate Regions in a Danish Population* FREE TO VIEW

Charlotte Brasch Andersen, MSc; Dorte Larsen; Annette Haagerup, MD; Joergen Vestbo, DMSc; Torben A. Kruse, PhD
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*From the Department of Clinical Biochemistry and Clinical Genetics (Mss. Andersen and Larsen, and Dr. Kruse), Odense University Hospital, Odense, Denmark; the Department of Human Genetics (Dr. Haagerup), University of Aarhus, Aarhus, Denmark; and the Department of Respiratory Medicine (Mr. Vestbo), University of Copenhagen, Copenhagen, Denmark.

Correspondence to: Charlotte Brasch Andersen, MSc, Department of Clinical Biochemistry and Clinical Genetics, KKA, Odense University Hospital, DK-5000 Odense, Denmark; e-mail: charlotte.b.andersen@ouh.fyns-amt.dk

Chest. 2002;121(3_suppl):88S-89S. doi:10.1378/chest.121.3_suppl.88S-a
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Allergic diseases affect approximately one fifth of the general population in the Western world, and their frequencies seem to be increasing. Asthma is one of the most common chronic diseases. Family and twin studies have shown that a genetic predisposition is a very substantial risk factor for developing asthma and other atopic diseases. The genes and mode of inheritance behind these complex diseases are still largely unknown. Numerous association studies have been performed trying to identify the genes that are involved in asthma and atopy, but there have been no clear-cut conclusions. Family-based linkage analysis enables the identification of disease genes without knowing the specific mechanisms behind the disease.

The purpose of this study was to identify the genes involved in asthma and other atopic diseases in a Danish population. Several clinical population samples are being used for this purpose. One hundred forty asthma sib-pair families that have been thoroughly investigated clinically are now being genotyped in candidate regions. The families are genotyped using 120 microsatellite markers spaced at approximate 3-cm distance in seven candidate regions. These candidate regions include regions on chromosomes 5q, 6p, and 12q and four regions not previously associated with atopy. These regions have been suggested from a genome scan of another Danish atopy sample. Multipoint affected sib-pair linkage analysis is performed using a computer program (MAPMAKER/SIBS; Whitehead/Massachusetts Institute of Technology Center for Genome Research; Cambridge, MA). The results of the multipoint sib-pair analyses in the candidate regions on chromosome 6p25.3–24.1 and 12q23–24.31 show no linkage to asthma.




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