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A Search for Linkage to Atopic Asthma in Candidate Regions in a Danish Population*

Charlotte Brasch Andersen, MSc; Dorte Larsen; Annette Haagerup, MD; Joergen Vestbo, DMSc; Torben A. Kruse, PhD
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*From the Department of Clinical Biochemistry and Clinical Genetics (Mss. Andersen and Larsen, and Dr. Kruse), Odense University Hospital, Odense, Denmark; the Department of Human Genetics (Dr. Haagerup), University of Aarhus, Aarhus, Denmark; and the Department of Respiratory Medicine (Mr. Vestbo), University of Copenhagen, Copenhagen, Denmark.

Correspondence to: Charlotte Brasch Andersen, MSc, Department of Clinical Biochemistry and Clinical Genetics, KKA, Odense University Hospital, DK-5000 Odense, Denmark; e-mail: charlotte.b.andersen@ouh.fyns-amt.dk



Chest. 2002;121(3_suppl):88S-89S. doi:10.1378/chest.121.3_suppl.88S-a
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Allergic diseases affect approximately one fifth of the general population in the Western world, and their frequencies seem to be increasing. Asthma is one of the most common chronic diseases. Family and twin studies have shown that a genetic predisposition is a very substantial risk factor for developing asthma and other atopic diseases. The genes and mode of inheritance behind these complex diseases are still largely unknown. Numerous association studies have been performed trying to identify the genes that are involved in asthma and atopy, but there have been no clear-cut conclusions. Family-based linkage analysis enables the identification of disease genes without knowing the specific mechanisms behind the disease.

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