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Tumor Necrosis Factor Gene Polymorphisms and the Variable Presentation and Outcome of Community-Acquired Pneumonia*

Richard G. Wunderink, MD, FCCP; Grant W. Waterer, MBBS, FCCP; Rita M. Cantor, PhD; Michael W. Quasney, MD, PhD
Author and Funding Information

*From Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN.

Correspondence to: Richard G. Wunderink, MD, FCCP, 501 Crews Wing, Methodist Healthcare, 1265 Union Ave, Memphis, TN 38104; e-mail: wunderir@methodisthealth.org



Chest. 2002;121(3_suppl):87S. doi:10.1378/chest.121.3_suppl.87S
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Tumor necrosis factor (TNF)-α is an integral part of the immune response to infection. A number of polymorphisms in or near the TNF-α gene are associated with variability in TNF-α production. The three polymorphisms with the best documented in vivo and in vitro effect on TNF-α production are the TNF-α-238, TNF-α-308, and lymphotoxin (LT)-α + 250 loci. At each locus, a G to A transition is associated with greater TNF-α production. We hypothesized that the A alleles of these three polymorphisms would be associated with greater mortality and a greater risk of septic shock in patients with community-acquired pneumonia (CAP).

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