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Impact of Cytokine Gene Polymorphisms on Outcomes of Coronary Artery Bypass Graft Surgery*

Sachin Yende, MD; Michael Quasney, MD, PhD; Q. Zhang, BS; Kristi Frederick, RN; Lori Kessler, PharmD; Richard G. Wunderink, MD, FCCP
Author and Funding Information

*From Methodist Healthcare and University of Tennessee, Memphis, TN.

Correspondence to: Sachin Yende, MD, 501 Crews Wing, Methodist Healthcare, 1265 Union Ave, Memphis, TN 38104; e-mail: yende@juno.com



Chest. 2002;121(3_suppl):86S. doi:10.1378/chest.121.3_suppl.86S
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A potential source of complications after coronary artery bypass graft surgery (CABG) includes release of proinflammatory and anti-inflammatory cytokines like tumor necrosis factor (TNF)-α and interleukin (IL)-10, respectively. These are released secondary to ischemia-reperfusion injury, exposure of blood to bypass circuit, products of complement system, and/or endotoxin release from the GI tract. The G → A transitions at − 308 site within the promoter region of the TNF-α gene and + 250 site within the first intron of the TNF-β gene is associated with elevated levels of TNF-α. Similarly, the G → A transition at − 1082 site within the promoter region of the IL-10 gene is associated with lower IL-10 levels. We hypothesize that polymorphisms within these genes will be associated with variable outcomes after CABG.

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