A potential source of complications after coronary artery bypass
graft surgery (CABG) includes release of proinflammatory and
anti-inflammatory cytokines like tumor necrosis factor (TNF)-α and
interleukin (IL)-10, respectively. These are released secondary to
ischemia-reperfusion injury, exposure of blood to bypass circuit,
products of complement system, and/or endotoxin release from the GI
tract. The G → A transitions at − 308 site within the promoter
region of the TNF-α gene and + 250 site within the first intron of
the TNF-β gene is associated with elevated levels of TNF-α.
Similarly, the G → A transition at − 1082 site within the
promoter region of the IL-10 gene is associated with lower IL-10
levels. We hypothesize that polymorphisms within these genes will be
associated with variable outcomes after CABG.