lipopolysaccharide (LPS) evokes several functional responses in the
polymorphonuclear leukocyte (PMN) that contribute to innate immunity.
While certain responses, such as adhesion and synthesis of tumor
necrosis factor-α, are inhibited by pretreatment with an inhibitor of
p38 mitogen-activated protein kinase (MAPk), others, such as actin
assembly, are unaffected. The aim of the present study was to
investigate the changes in PMN gene transcription and protein
expression following LPS exposure and their dependence on p38 MAPk