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Genetics and Gene Expression in Pulmonary Hypertension*: Parker B. Francis Lecture

James E. Loyd, MD
Author and Funding Information

*From Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: James E. Loyd, MD, Professor of Medicine, Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1211 22nd Ave S, Nashville, TN; e-mail: jim.loyd@mcmail.vanderbilt.edu



Chest. 2002;121(3_suppl):46S-50S. doi:10.1378/chest.121.3_suppl.46S
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Extract

The prototype of clinical pulmonary hypertension is primary pulmonary hypertension (PPH), for which interesting new information is available. PPH is a severe and progressive disease with a mean survival of < 3 years without treatment. The central feature of PPH is widespread obstructive lesions of small pulmonary arteries. Despite dramatic advances in many aspects of PPH during the past decade, including improved diagnosis, new understanding of biological mediators, and the development of the first effective therapy, the possibility of prevention or cure seems elusive unless the central basic mechanisms are identified and characterized.

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