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Acute Lung Injury Does Not Impair Adenoviral-Mediated Gene Transfer to the Alveolar Epithelium*

Vidas Dumasius; Michael Mendez, MD; Gökhan M. Mutlu, MD; Phillip Factor, DO, FCCP
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*From Pulmonary and Critical Care Medicine (Drs. Dumasius and Mendez), Evanston Hospital, Evanston; and Northwestern University Medical School (Drs. Mutlu and Factor), Chicago, IL.

Correspondence to: Phillip Factor, DO, FCCP, Pulmonary and Critical Care Medicine, Evanston Northwestern Healthcare, 2650 Ridge Rd, Evanston, IL 60201; e-mail: pfactor@northwestern.edu



Chest. 2002;121(3_suppl):33S-34S. doi:10.1378/chest.121.3_suppl.33S
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Studies15 have shown that overexpression of genes such as superoxide dismutase, catalase, Na,K-adenosine triphosphatase, and interleukin-10 in the distal lung can protect from acute injury. All of these prior studies transduced the lungs prior to the onset of injury. In order for gene transfer to be clinically useful for acute lung injury (ALI), it will be necessary to transduce the alveolar epithelium after the onset of injury. However, the pathobiology of ALI includes alveoli filled with fluid, fibrin, inflammatory cells, and cytokines, all of which can impair alveolar gene transfer.6 These biomechanical processes represent formidable hurdles that have limited the development of gene therapy for ALIs.

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