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The Genetic Predisposition to Interstitial Lung Disease*: Functional Relevance

R. M. du Bois, MD
Author and Funding Information

*From Royal Brompton Hospital. London, UK.

Correspondence to: R. M. du Bois, MD, Consultant Physician, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK; e-mail: r.dubois@rbh.nthames.nhs.uk



Chest. 2002;121(3_suppl):14S-20S. doi:10.1378/chest.121.3_suppl.14S
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Extract

The approach to the genetic predisposition to diffuse lung disease (previously known as interstitial lung disease) poses a number of unique problems. The diffuse lung diseases comprise a large number of distinct clinical diseases. Of these, the idiopathic interstitial pneumonias are of particular importance because they include idiopathic pulmonary fibrosis (IPF), the most lethal form of diffuse lung disease, together with a number of diffuse lung disorders that have been (and continue to be) misdiagnosed as IPF. Each diffuse lung disease is likely to be a genetically complex disease with several genetic loci conferring variable risk of developing disease or modifying its severity together with an equally variable contribution from environmental triggers.

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