0
Reviews |

Interaction of Hemostatic Genetics With Hormone Therapy*: New Insights To Explain Arterial Thrombosis in Postmenopausal Women

Joel B. Braunstein, MD; Dawn Warner Kershner, DO; Paul Bray, MD; Gary Gerstenblith, MD; Steven P. Schulman, MD; Wendy S. Post, MD, MS; Roger S. Blumenthal, MD, FCCP
Author and Funding Information

*From the The Johns Hopkins Ciccarone Center for Prevention of Heart Disease (Drs. Braunstein, Kershner, Gerstenblith, Schulman, Post, and Blumenthal), Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD; and the Thrombosis Research Section (Dr. Bray), Department of Medicine, Baylor College of Medicine, Houston, TX.

Correspondence to: Roger S. Blumenthal, MD, FCCP, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Carnegie 538, Baltimore, MD 21287; e-mail: rblument@jhmi.edu



Chest. 2002;121(3):906-920. doi:10.1378/chest.121.3.906
Text Size: A A A
Published online

Genetic variants of key hemostatic mediators increasingly have been proposed as risk factors for atherothrombosis. The Hormone and Estrogen/Progestin Replacement Study group recently reported that the initiation of estrogen replacement in postmenopausal women with known coronary heart disease is associated with an early increase in cardiovascular events. A putative genetic susceptibility factor has been proposed a potential mediator of this increased event risk. This review outlines the recent literature to support the premise for this important proposal. Genetic profiling has great potential to improve the safety and efficacy of individualized pharmacotherapy in postmenopausal women and other at-risk populations for the prevention of cardiovascular disease.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543