0
Clinical Investigations: ASTHMA |

Marginal Utility of Montelukast for Persistent Asthma*

David A. Mathison, MD,; James A. Koziol, PhD
Author and Funding Information

*From the Division of Allergy, Asthma and Immunology (Dr. Mathison), Scripps Clinic, and the Department of Molecular and Experimental Medicine (Dr. Koziol), The Scripps Research Institute, La Jolla, CA.

Correspondence to: David A. Mathison, MD, Scripps Clinic, Division of Allergy, Asthma and Immunology, 10666 North Torrey Pines Rd, 205W, La Jolla, CA 92037;



Chest. 2002;121(2):334-337. doi:10.1378/chest.121.2.334
Text Size: A A A
Published online

Background: The efficacy of a new pharmacologic agent for asthma, in this instance the leukotriene receptor antagonist montelukast, is determined in controlled trials in research subjects. The utility of a new drug is determined by multiple uncontrollable factors in individual patients.

Objective: To assess the utility of montelukast in the management of persistent asthma.

Design: Observational, retrospective.

Setting: Suburban multispecialty medical clinic.

Methods: From April 1998, montelukast was prescribed for 110 patients with persistent but controlled asthma, primarily for the corticosteroid-sparing effect. Outcomes after 1 year were determined from audits of medical records and responses to questionnaires.

Results: At least 56% of patients continued receiving montelukast for the entire year. However, compared to those patients who had discontinued montelukast therapy, those who continued receiving it had no difference in the use of inhaled or systemic corticosteroid or inhaled β2-agonist therapy.

Conclusion: Montelukast had marginal utility in the management of these adult patients with controlled persistent asthma.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
Long-term management of asthma.
Finnish Medical Society Duodecim | 1/11/2008
Allergic Rhinitis and its Impact on Asthma (ARIA) 2010 revision.
Allergic Rhinitis and its Impact on Asthma Workshop Group | 1/11/2008
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543