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Opinions/Hypotheses |

Airway Hyperresponsiveness and Calcium Handling by Smooth Muscle*: A “Deeper Look”

Krishnan Parameswaran, MD, FCCP; Luke J. Janssen, PhD; Paul M. O’Byrne, MB, FCCP
Author and Funding Information

*From the Asthma Research Group, Department of Medicine, St. Joseph’s Healthcare & McMaster University, Hamilton, ON, Canada.

Correspondence to: Paul M. O’Byrne, MB, FCCP, Firestone Institute for Respiratory Health, St. Joseph’s Healthcare, 50 Charlton Ave East, Hamilton, ON L8N 4A6, Canada; e-mail: obyrnep@mcmaster.ca



Chest. 2002;121(2):621-624. doi:10.1378/chest.121.2.621
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We propose that abnormal calcium handling by the airway smooth muscle may be an important determinant of airway hyperresponsiveness. The amplitude, frequency, or localization of Ca2+ oscillations in the smooth muscle may determine the degree of airway sensitivity and reactivity, which are characteristic features of asthma.

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