0
Clinical Investigations: BRONCHIECTASIS |

Exhaled and Sputum Nitric Oxide in Bronchiectasis*: Correlation With Clinical Parameters

Kenneth W. Tsang, MD, FCCP; Raymond Leung, BSc; Peter Chin-wan Fung, PhD; Shelley L. Chan, MMedSc; George L. Tipoe, MD, PhD; Gaik C. Ooi, MD; Wah K. Lam, MD
Author and Funding Information

*From the Departments of Medicine (Drs. Tsang, Chin-wan Fung, Lam, Mr. Leung, and Ms. Chan), Anatomy (Dr. Tipoe), and Diagnostic Radiology (Dr. Ooi), The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.

Correspondence to: Kenneth W. Tsang, MD, FCCP, Associate Professor and Honorary Consultant Physician, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Rd, Hong Kong SAR, China; e-mail: kwttsang@hkucc.hku.hk



Chest. 2002;121(1):88-94. doi:10.1378/chest.121.1.88
Text Size: A A A
Published online

Study objectives: Although there has been tremendous attention on endogenous nitric oxide (NO) production in many respiratory and systemic diseases, little is known on NO production in bronchiectasis.

Design and setting: We determined exhaled and sputum NO levels in 109 patients with stable bronchiectasis (71 women; mean ± SD age, 58.2 ± 14.1 years) and 78 control subjects (39 women; mean age, 56.7 ± 12.1 years) by using an automatic chemiluminescence analyzer.

Measurements and results: There was no significant difference in exhaled NO between patients with bronchiectasis and control subjects (p = 0.11). Bronchiectasis patients with Pseudomonas aeruginosa infection had a significantly lower exhaled, but not sputum, NO levels than their counterparts and control subjects (p = 0.04 and p = 0.009, respectively). Exhaled NO correlated with 24-h sputum volume in P aeruginosa-infected patients (r = − 0.36; p = 0.002). After adjustment for sputum volume and number of bronchiectatic lung lobes, P aeruginosa-infected patients still had lower exhaled NO levels than their counterparts (p = 0.01). There was no correlation between exhaled NO with FEV1, FVC, and the number of bronchiectatic lung lobes (p > 0.05). Sputum NO levels were not different between patients and control subjects (p = 0.64), and had no correlation with clinical parameters.

Conclusion: Exhaled NO appears to be reduced among bronchiectasis patients with P aeruginosa infection independent of other clinical parameters, and further studies on the potential mechanisms and pathogenetic implications of this reduction should be pursued.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543