Study objective: To report the outcome of patients with
autologous peripheral blood stem cell transplantation (PBSCT) receiving
Setting: Active hematopoietic
stem cell transplantation center and a university hospital medical
Patients: Patients with autologous PBSCT
receiving mechanical ventilation.
Method: A review of
the medical records of patients with autologous PBSCT receiving
mechanical ventilation. Data collection was restricted to the first
episode of mechanical ventilation.
Results: A total of
78 autologous PBSCT patients received mechanical ventilation for > 24
h. Twenty patients (26%) were extubated and discharged alive from the
hospital. Thirteen hospital survivors (60%) were alive at 6 months.
Lung injury (LI), vasopressor use, and hepatic and renal failure (HRF)
were used to predict survival after mechanical ventilation. Sixty
patients (76%) had no organ failure, or had isolated LI or only
required treatment with vasopressors. Their hospital survival and
6-month survival were 32% and 20%, respectively. Hospital and 6-month
survival for the patients with HRF or LI and vasopressor use was 6%
and 0%, respectively.
mechanical ventilation and aggressive ICU support is justified for
autologous PBSCT patients receiving mechanical ventilation with no
organ failure, or who have only isolated LI, or who only require
treatment with vasopressors.