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Exercise Not Asthma

R. Andrew McIvor, MD, MSc
Author and Funding Information

Affiliations: Halifax, Nova Scotia, Canada 
 ,  Dr. McIvor is Associate Professor of Medicine, Dalhousie University, and Staff Respirologist, Queen Elizabeth II Health Sciences Centre.

Correspondence to: R. Andrew McIvor, MD, MSc, Staff Respirologist, Queen Elizabeth II Health Sciences Centre, 1796 Summer St, Room 4479, Halifax, Nova Scotia, Canada B3H 3A7; e-mail: amcivor@is.dal.ca



Chest. 2001;120(5):1434-1435. doi:10.1378/chest.120.5.1434
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Although environmental factors are clearly important determinants of asthma, numerous studies have revealed that asthma also has strong genetic components. The genetic answer to the asthma conundrum is unlikely to be simple, as multiple regions of the human genome are likely to contain susceptibility genes for asthma.

In this issue of CHEST (see page 1474), Barr et al report that activity status and obesity might modify the influence of genetic polymorphisms on patients with adult-onset asthma. They suggest the presence of Gly16 allele is associated with adult-onset asthma in sedentary women, implying that the relationship betweenβ 2-adrenoceptor polymorphisms in adult-onset asthma is modifiable by environmental factors. This group has recently shown that a similar gene environment interaction may exist betweenβ 2-adrenoceptor polymorphisms and smoking.1

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