0
Clinical Investigations: PULMONARY VASCULATURE |

Big Endothelin-1 and Endothelin-1 Plasma Levels Are Correlated With the Severity of Primary Pulmonary Hypertension*

Christoph Rubens, MD; Ralf Ewert, MD; Michael Halank, MD; Roland Wensel, MD; Hans-Dieter Orzechowski, MD; Heinz-Peter Schultheiss, MD; Gert Hoeffken, MD
Author and Funding Information

*From the Department of Cardiology and Pulmonology (Drs. Rubens and Schultheiss) and Institute of Clinical Pharmacology and Toxicology (Dr. Orzechowski), Benjamin Franklin Hospital, Free University of Berlin, Berlin; German Heart Institute Berlin (Drs. Ewert and Wensel) and Department of Internal Medicine I and Pulmonology (Drs. Halank and Hoeffken), Carl Gustav Carus Hospital, University of Dresden, Dresden, Germany.

Correspondence to: Christoph Rubens, MD, Department of Cardiology and Pulmonology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany; e-mail: ChristophRubens@aol.com



Chest. 2001;120(5):1562-1569. doi:10.1378/chest.120.5.1562
Text Size: A A A
Published online

Study objectives: Primary pulmonary hypertension (PPH) is a rare disease of unknown etiology that is characterized by a poor prognosis. This study was undertaken to investigate possible correlations between endothelin (ET)-1 and big ET-1 plasma levels and the severity of PPH.

Patients: Sixteen consecutive patients with PPH were included.

Interventions: Hemodynamics of patients with PPH were measured by right-heart catheterization, and a 6-min walk test was performed.

Measurements: Plasma levels of the biologically active peptide ET-1 and its precursor big ET-1 were determined in blood samples from the pulmonary artery, peripheral artery, and peripheral vein by radioimmunoassay.

Results: A strong correlation was shown between pulmonary vascular resistance, mean pulmonary artery pressure, cardiac output, cardiac index, 6-min walk data, and elevated plasma levels of big ET-1 as well as mature ET-1 plasma levels at all sites of blood sampling (p < 0.01 and p < 0.05, respectively).

Conclusions: Levels of circulating ET-1 might become a prognostic marker for patients with PPH and serve as a tool for the selection of patients who may benefit from treatment with ET-receptor antagonists.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543