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Clinical Investigations: COPD |

Polymorphism of the β2-Adrenoceptor in COPD in Chinese Subjects*

Li-Ing Ho, MD, FCCP; Horng-Jyh Harn, MD, PhD; Cheng-Jueng Chen, MD; Nu-Man Tsai, MS
Author and Funding Information

*From the Department of Respiratory Care (Dr. Ho), Veterans General Hospital-Taipei, Taipei, Taiwan; Department of Pathology (Dr. Harn), Tri-Service General Hospital, Taipei, Taiwan; Department of General Surgery (Dr. Chen), Tri-Service General Hospital, Taipei, Taiwan; and Graduate Institute of Medical Sciences (Ms. Tsai), National Defense Medical Center, Taipei, Taiwan.

Correspondence to: Li-Ing Ho, MD, FCCP, Department of Respiratory Care, Veterans General Hospital-Taipei, No. 201, Section 2, Shih-Pai Rd, Taipei, Taiwan; e-mail: liho@vghtpe.gov.tw



Chest. 2001;120(5):1493-1499. doi:10.1378/chest.120.5.1493
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Study objectives: To assess the frequencies of three polymorphisms at amino acid positions 16, 27, and 164 of theβ 2-adrenoceptor (β2-AR) gene and their effects on COPD patients.

Design: Prospective, case-control study

Patients: Sixty-five patients with COPD and 41 healthy subjects were included.

Measurements: Polymorphisms of the β2-AR coding block were delineated using an allele-specific polymerase chain reaction (PCR) approach. The allele-specific PCR technique was verified by direct dideoxy sequencing of PCR products. Pulmonary function tests were performed in all patients.

Results: The Arg16β 2-AR polymorphism was less prevalent in COPD patients than in healthy populations (p = 0.01). A significant correlation (p < 0.018) between the Gln27 β2-AR polymorphism and FEV1 percent predicted value was found. Patients with the Gln27 polymorphism had a higher percentage of low FEV1 percent predicted than did patients with the GlnGlu and GluGlu variants.

Conclusions: The polymorphism of Gly16 may increase the patient’s susceptibility to the development of COPD. The Gln27 β2-AR polymorphism may be associated with the severity of COPD in a Chinese population.

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