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Opinions/Hypotheses |

Granulocyte Colony-Stimulating Factor or Neutrophil-Induced Pulmonary Toxicity: Myth or Reality?*: Systematic Review of Clinical Case Reports and Experimental Data

Elie Azoulay, MD; Habiba Attalah; Alain Harf, MD, PhD; Benoı̂t Schlemmer, MD; Christophe Delclaux, MD, PhD
Author and Funding Information

*From the INSERM U 492, Université Paris XII, Faculté de Médecine de Créteil, France; Service de Physiologie, Explorations Fonctionelles, Hôpital Henri Mondor, Paris, France; Assistance Publique, Hôpitaux de Paris, France; Service de Réanimation Médicale, Hôpital Saint Louis, Paris, France.

Correspondence to: Elie Azoulay, MD, Faculté de Médecine de Créteil, 8, rue du Général Sarrail, 94010 Créteil, France; e-mail: elie.azoulay@creteil.inserm.fr



Chest. 2001;120(5):1695-1701. doi:10.1378/chest.120.5.1695
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Human granulocyte colony-stimulating factor (G-CSF) is the most important regulatory cytokine that is capable of stimulating the production of neutrophils from committed hematopoietic progenitor cells both in vitro and in vivo.12 G-CSF both increases neutrophil counts and enhances and primes many neutrophil functions, suggesting a role for this growth factor in host defenses not only in neutropenic patients but also in many non-neutropenic immunocompromised patients.

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