0
Clinical Investigations: ASTHMA |

Effect of Inhaled Budesonide on Bronchial Hyperresponsiveness in Adolescents With Clinical Remission of Asthma*

Young Yull Koh, MD; Yong Han Sun, MD; Hyung Suk Lim, MD; Chang Keun Kim, MD; Soo Jong Hong, MD
Author and Funding Information

*From the Department of Pediatrics and Clinical Research Institute (Drs. Koh, Sun, and Lim), Seoul National University Hospital, Seoul; Department of Pediatrics (Dr. Kim), Inje University Sanggye Paik Hospital, Seoul; and Department of Pediatrics (Dr. Hong), Ulsan University College of Medicine, Seoul, Korea.

Correspondence to: Young Yull Koh, MD, Department of Pediatrics, Seoul National University Hospital, 28 yongon-dong, Chongno-gu, Seoul 110–744, Korea; e-mail: kohyy@plaza.snu.ac.kr



Chest. 2001;120(4):1140-1146. doi:10.1378/chest.120.4.1140
Text Size: A A A
Published online

Study objective: Many children with asthma go into long-term clinical remission at adolescence, but bronchial hyperresponsiveness (BHR) persists in some of these subjects. The regular use of inhaled corticosteroids improves BHR in patients with symptomatic asthma. The aim of this study was to determine whether BHR in adolescents with asthma remission could be reduced by prolonged treatment with inhaled corticosteroids.

Design: A randomized, double-blind, placebo-controlled, parallel study.

Patients: Thirty-seven adolescents with BHR and long-term remission of their asthma (neither symptoms nor any medication use during the previous 2 years).

Intervention: Subjects received inhaled budesonide (two 200-μg puffs bid; budesonide group, n = 19) or identical placebo (placebo group, n = 18) for 9 months. A separate group of patients with symptomatic asthma (symptomatic group, n = 19), using the same regimen of budesonide, was also studied.

Measurements and results: The provocative concentration of methacholine producing a 20% fall in FEV1 (PC20) was measured before and every 3 months during treatment. There was no significant difference among the three groups for the baseline PC20. In neither the placebo nor the budesonide group did the geometric mean of PC20 change significantly over the 9-month period. In contrast, a significant increase in PC20 was noted in the symptomatic group as a result of the budesonide treatment.

Conclusion: Our data have shown that budesonide inhaled regularly for 9 months did not cause a significant improvement in the BHR of adolescents with long-term asthma remission. This suggests that the mechanism underlying BHR in this clinical setting may be different from that in symptomatic asthma.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
Asthma in pregnancy.
American College of Obstetricians and Gynecologists | 9/19/2008
Inhaled corticosteroids for the treatment of chronic asthma in children under the age of 12 years.
National Institute for Health and Clinical Excellence (NICE) | 1/31/2008
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543