0
Clinical Investigations: PULMONARY VASCULATURE |

Primary Pulmonary Hypertension Is Not Associated With Scleroderma-Like Changes in Nailfold Capillaries*

Eric L. Greidinger, MD; Sean P. Gaine, MBBCh, FCCP; Robert A. Wise, MD, FCCP; Christy Boling, BA; Traci Housten-Harris, RN; Fredrick M. Wigley, MD
Author and Funding Information

*From the Division of Immunology and Rheumatology (Dr. Greidinger), University of Missouri, Columbia, MO; and the Divisions of Rheumatology (Dr. Wigley and Ms. Boling) and Pulmonary and Critical Care Medicine (Drs. Gaine and Wise and Ms. Housten-Harris), Johns Hopkins University, Baltimore, MD.

Correspondence to: Eric L. Greidinger, MD, MA427 Health Sciences Center, Columbia, MO 65212; e-mail: greidingere@health.missouri.edu



Chest. 2001;120(3):796-800. doi:10.1378/chest.120.3.796
Text Size: A A A
Published online

Study objectives: To determine whether primary pulmonary hypertension (PPH) is associated with scleroderma-like changes in nailfold capillaries.

Design: Blinded, prospective, case-control study.

Setting: University medical centers in Baltimore, MD.

Patients: Thirty-seven patients with PPH, 15 patients with scleroderma, and 13 healthy control subjects.

Measurements: Subjects underwent nailfold capillary videomicroscopy of the fourth digits of both hands. Capillary images were evaluated by two blinded, trained graders according to standardized criteria for the presence of scleroderma nailfold changes.

Results: The prevalence of scleroderma-associated nailfold changes in patients with PPH (1 of 37 patients) was dramatically lower than that in patients with scleroderma (9 of 15 patients; p < 0.0001). The distribution of nailfold grades for the PPH patients was indistinguishable from that of the healthy control subjects.

Conclusion: PPH is not associated with scleroderma-like vasculopathy of nailfold capillaries.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543