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Pulmonary Small Lymphocytic Lymphoma (Mucosa-Associated Lymphoid Tissue Type) Associated With Pulmonary Hyalinizing Granuloma*

Yafei Ren, MD, PhD; ElizabethAnn N. Raitz, MD; Kyo Rak Lee, MD; Susan K. Pingleton, MD, FCCP; Ossama Tawfik, MD, PhD
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*From the Departments of Pathology and Laboratory Medicine (Drs. Ren and Tawfik), Internal Medicine (Drs. Raitz and Pingleton), and Radiology (Dr. Lee), University of Kansas Medical Center, Kansas City, KS.

Correspondence to: Ossama Tawfik, MD, PhD, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160; e-mail: otawfik@kumc.edu



Chest. 2001;120(3):1027-1030. doi:10.1378/chest.120.3.1027
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A case of pulmonary hyalinizing granuloma (PHG) and concomitant low-grade, small lymphocytic lymphoma of the lung is presented. This is the first occurrence of pulmonary lymphoma in patients with PHG ever reported. The infiltrates around a left lower lobe nodule with left pleural effusion and thickening seen on chest CT were histologically proven to be lymphomatous infiltrates of the lung, pleura, and chest wall muscle. We believe that the lymphoma developed around the nodule and spread to the pleura and muscle in our patient. When infiltrates around the nodules, pleural effusion, or adenopathy are developed in a patient with proven PHG, close follow-up, biopsy, or careful cytology should be seriously considered to rule out a developing lymphoma.

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