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Clinical Investigations: TUBERCULOSIS |

Treatment Experience of Multidrug-Resistant Tuberculosis in Florida, 1994–1997*

Masahiro Narita, MD; Pedro Alonso, MD, PhD; Michael Lauzardo, MD; Elena S. Hollender, MD; Arthur E. Pitchenik, MD, FCCP; David Ashkin, MD, FCCP
Author and Funding Information

*From the A.G. Holley State Tuberculosis Hospital (Drs. Hollender and Ashkin), Lantana, FL; Florida Department of Health, Bureau of Tuberculosis Control and Prevention (Drs. Narita and Lauzardo); Division of Pulmonary and Critical Care Medicine (Dr. Alonso), University of Miami School of Medicine; VA Medical Center (Dr. Pitchenek), Miami, FL.

Correspondence to: David Ashkin, MD, FCCP, Medical Executive Director, A.G. Holley State Tuberculosis Hospital, 1199 West Lantana Rd, Lantana, FL 33462; e-mail: David_Ashkin@doh. state.fl.us



Chest. 2001;120(2):343-348. doi:10.1378/chest.120.2.343
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Objective: To study the clinical characteristics and results of patients with diagnoses of multidrug-resistant tuberculosis (MDR-TB) in the state of Florida.

Methods: Retrospective chart review of all patients (n = 81) with diagnoses of MDR-TB in Florida between January 1, 1994, and July 31, 1997.

Results: The average number of resistant drugs was 4.8 (range, 2 to 11). Of 81 patients, 46 patients (57%) completed adequate therapy, 26 patients (32%) died, and 9 patients (11%) never completed a satisfactory course of treatment. Patients who received at least part of their therapy at A. G. Holley State Hospital, a specialized tuberculosis (TB) treatment center, had significantly higher treatment completion rates (79%) than those treated as outpatients alone (48% treatment completion rate, p < 0.001), even after the exclusion of patients who were acutely ill and died within 2 months of diagnosis.

Conclusion: In Florida, a specialized TB care program for MDR-TB, including at least partial inpatient therapy, yielded higher treatment completion rates compared to outpatient treatment alone.


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