0
Clinical Investigations: TECHNIQUES |

Exhaled Carbon Monoxide and Nitric Oxide in COPD*

Paolo Montuschi, MD; Sergei A. Kharitonov, MD, PhD; Peter J. Barnes, DM
Author and Funding Information

*From the Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, London, UK.

Correspondence to: Paolo Montuschi, MD, Department of Pharmacology, Catholic University of the Sacred Heart, Largo F. Vito, 1, 00168 Roma, Italy; e-mail: p.montuschi@ic.ac.uk



Chest. 2001;120(2):496-501. doi:10.1378/chest.120.2.496
Text Size: A A A
Published online

Study objectives: To investigate whether exhaled carbon monoxide (CO) and nitric oxide (NO) could be used as noninvasive in vivo biomarkers of oxidative stress in the lungs of patients with COPD.

Design: Single-center cross-sectional study.

Patients: Ten healthy nonsmokers, 12 smokers, 15 stable ex-smokers with COPD, and 15 stable current smokers with COPD.

Interventions: Subjects attended the outpatient clinic on one occasion for pulmonary function tests and exhaled CO and NO measurements.

Measurements and results: Mean (± SEM) CO levels in ex-smokers with COPD were higher (7.4 ± 1.9 ppm; p < 0.05) than in nonsmoking control subjects (3.0 ± 0.3 ppm) but were lower than in current smokers with COPD (20.0 ± 2.6 ppm; p < 0.001). There was no correlation between exhaled CO and NO. There was no correlation between CO and lung function tests in any group of patients. Exhaled NO was higher in ex-smokers with COPD (12.0 ± 1.0 parts per billion [ppb]; p < 0.001) than in healthy nonsmokers (6.5 ± 0.6 ppb) and in current smokers with COPD (7.6 ± 1.1 ppb; p < 0.01) compared to healthy smokers (3.3 ± 0.4 ppb). Ex-smokers with COPD had higher exhaled NO levels than did current smokers with COPD (p < 0.001) There was a negative correlation between exhaled NO and FEV1 in both ex-smokers with COPD (r = −0.60; p < 0.02) and current smokers with COPD (r = −0.59; p < 0.02).

Conclusion: The measurement of exhaled CO and NO may represent a new method for the noninvasive monitoring of airway inflammation and oxidant stress in COPD ex-smokers. Exhaled CO and NO are strongly affected by cigarette smoking, which limits their usefulness as biomarkers in current smokers.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543