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Communications to the Editor |

Cardiac Thrombus in Behçet Disease FREE TO VIEW

Satoru Yoshida, MD; Kenji Fujimori, MD, PhD; Masato Hareyama, MD, PhD; Tomoaki Nakata, MD, PhD
Author and Funding Information

Sapporo Medical University School of Medicine Sapporo, Japan

Correspondence to: Satoru Yoshida, MD, Department of Radiology, Muroran City General Hospital, Yamate-chou 3–8-1, Muroran 051-8512, Japan; e-mail: satyoshi@chive.ocn.ne.jp



Chest. 2001;120(2):688-689. doi:10.1378/chest.120.2.688-a
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To the Editor:

We read with interest the review by Mogulkoc and colleagues (August 2000)1regarding intracardiac thrombus in 24 patients with Behçet disease previously published in 21 reports. It is also noted that the authors suggest a unique geographic distribution of this condition in the Mediterranean basin and the Middle East. However, several important articles24 from the Far East are not mentioned in the review article, although it is well-known that Japan is one of specific areas to have a high prevalence of Behçet disease. We report herein a case of Behçet disease with cardiac and pulmonary arterial thrombus from a radiologic point of view.

A 19-year-old Japanese man was admitted to our hospital in January 1996 due to hemoptysis and right heart failure. He had undergone the surgical removal of right ventricular thrombus at another hospital 9 months previously. He received a diagnosis of incomplete Behçet disease based on oral ulceration, skin lesion, uveitis, and positive human leukocyte antigen-B51. Enhanced helical CT (Fig 1 , top, middle) revealed thrombus of the right atrium, right ventricle, and right pulmonary artery. Indium-111 platelet scintigraphy (Fig 1, bottom) showed strong uptakes in the right-sided heart and right pulmonary hiatus suggesting acute thrombus formations. Scintigraphy clarified the activity of thrombus and contributed to determining the therapeutic strategy against the serious complications of Behçet disease.

Helical CT can be helpful in the assessment of thoracic manifestations of Behçet disease including thrombus of the systemic veins, heart, and pulmonary arteries.2 To our knowledge, there have been no reports of the use of indium-111–labeled platelet scintigraphy in cardiac thrombus in Behçet disease.15 Scintigraphy can be used to determine whether a thrombus is acute or chronic.6

The selection of key words for a computerized search of the medical literature using the National Library of Medicine’s MEDLINE is important. Our case and several reported cases25 strongly suggest that the Far East should be included among the specific geographic distribution of patients with cardiac thrombus in Behçet disease.

Figure Jump LinkFigure 1. Enhanced helical CT showed thrombus of the right-sided heart (top) and right pulmonary artery (middle). Bottom: Scintigraphy showed abnormal accumulations in accordance with findings on helical CT.Grahic Jump Location

References

Mogulkoc, N, Burgess, MI, Bishop, PW (2000) Intracardiac thrombus in Behcet’s disease: a systematic review.Chest118,479-487. [CrossRef]
 
Ahn, JM, Im, JG, Ryoo, JW, et al Thoracic manifestations of Behcet syndrome: radiographic and CT findings in nine patients.Radiology1995;194,199-203. [CrossRef]
 
Imai, H, Sakakibara, M, Yoshida, K, et al Magnetic resonance imaging of cardiovascular thrombi [in Japanese].J Cardiogr1985;15,681-694
 
Yoshimura, H, Ishii, J, Watanabe, N, et al A case of cardiovascular Behcet’s disease detected as multiple nodular shadows on chest X-ray [in Japanese].Nihon Kyobu Shikkan Gakkai Zasshi1997;35,1074-1079
 
Yasuo, M, Nagano, S, Yazaki, Y, et al Pulmonary embolism due to right ventricular thrombus in a case of Behcet’s disease.Jpn Circ J1999;63,909-911. [CrossRef]
 
Kight, LC Scintigraphic methods for detecting vascular thrombus.J Nucl Med1993;34,554-561
 

Figures

Figure Jump LinkFigure 1. Enhanced helical CT showed thrombus of the right-sided heart (top) and right pulmonary artery (middle). Bottom: Scintigraphy showed abnormal accumulations in accordance with findings on helical CT.Grahic Jump Location

Tables

References

Mogulkoc, N, Burgess, MI, Bishop, PW (2000) Intracardiac thrombus in Behcet’s disease: a systematic review.Chest118,479-487. [CrossRef]
 
Ahn, JM, Im, JG, Ryoo, JW, et al Thoracic manifestations of Behcet syndrome: radiographic and CT findings in nine patients.Radiology1995;194,199-203. [CrossRef]
 
Imai, H, Sakakibara, M, Yoshida, K, et al Magnetic resonance imaging of cardiovascular thrombi [in Japanese].J Cardiogr1985;15,681-694
 
Yoshimura, H, Ishii, J, Watanabe, N, et al A case of cardiovascular Behcet’s disease detected as multiple nodular shadows on chest X-ray [in Japanese].Nihon Kyobu Shikkan Gakkai Zasshi1997;35,1074-1079
 
Yasuo, M, Nagano, S, Yazaki, Y, et al Pulmonary embolism due to right ventricular thrombus in a case of Behcet’s disease.Jpn Circ J1999;63,909-911. [CrossRef]
 
Kight, LC Scintigraphic methods for detecting vascular thrombus.J Nucl Med1993;34,554-561
 
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