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Acute Myopericarditis After Diphtheria, Tetanus, and Polio Vaccination*

Franck Boccara, MD; Nicole Benhaiem-Sigaux, MD; Ariel Cohen, MD, PhD
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*From the Service de Cardiologie (Drs. Boccara and Cohen), Saint Antoine University and Medical School, Paris; and Anatomopathology Department (Dr. Benhaiem-Sigaux), Henri Mondor University and Medical School, Creteil, France.

Correspondence to: Ariel Cohen, MD, PhD, Service de Cardiologie, Saint-Antoine University and Medical School, Assistance Publique-Hôpitaux de Paris and Université Pierre et Marie Curie, 184, rue du faubourg St-Antoine, 75571 Paris Cedex 12, France; e-mail: ariel.cohen@sat.ap-hop-paris.fr



Chest. 2001;120(2):671-672. doi:10.1378/chest.120.2.671
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We report the first case of myopericarditis after triple vaccination against diphtheria, tetanus, and poliovirus in a young adult. He presented with fever, acute chest pain, and diffuse ST-segment elevation 2 days after vaccination. Two-dimensional echocardiography findings were normal. Endomyocardial biopsy showed interstitial edema with diapedesis of erythrocytes. Laboratory findings showed inflammatory syndrome and elevated circulating immune complexes. He recovered within a few days with high-dose aspirin treatment and was without complications at 3-month follow-up. We discuss the different hypotheses for infective or hypersensitivity myocarditis.

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